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Latest News
2012 May 9th 18h30-20h00 Innovation evening. Presentation of new drug approvals 2011-2012 :
2012 April 18th: Science Day at the Hall of Theses from the University of Lille 1, organized by the Committee of Direction of Prim. Read More
Consult past events and seminars organized by PRIM : Read more
New article about PRIM in Le Nouvel Observateur : Read More
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List of the scientific projects that received grants
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PRIM-SP: Privileged structures - Natural-like compounds from keto-acids.(2008)
Coordinators:
- CNRS UMR8010 : Lydie Pelinski Lille2
- EA1043 : Nicolas Lebegue
- INSERM U761 : Guillaume Laconde, Rebecca Déprez-Poulain
Mission :
The project aims at designing and synthesizing chemical libraries to enrich the regional library with privileged structures inspired from natural products.
Objectives and Rationale:
Our regional screening library is a set of 45000 either lead-like, drug-like molecules or fragments (for structure-based discovery). In order to improve the set of more sophisticated compounds, that display for example quaternary centers and controlled chiral carbons, we develop the synthesis of privileged structures from a common template: keto-acids. These precursors allow the synthesis of enantiomers or diastereoisomers either in racemic or pure chiral form of piperidines, piperazines, lactams …A strong emphasis is put on green technologies using solvent-free microwave procedures or water based protocols. The main reactions used are the Ugi multicomponent reaction and the Meyers’ reaction a binucleophile-bielectrophile reaction type.
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