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SCIENCE > Publications

2012

  • Bousquet, T., Jida, M., Soueidan, M., Deprez-Poulain, R., Agbossou-Niedercorn, F., & Pelinski, L. Fast and Efficient solvent-free Passerini reaction. Tetrahedron Letters,2012, 53(3): 306-308 doi:10.1016/j.tetlet.2011.11.028
  • Beghyn, T., Julie, C., Leroux, F., Henninot, A., Reboule, I., Cos, P., Maes, L., & Deprez, B. P. Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds. Journal of Medicinal Chemistry,2012, 55(3) : 1274-1286 doi:10.1021/jm201422e
  • Flipo, M., Desroses, M., Lecat-Guillet, N., Villemagne, B., Blondiaux, N., Leroux, F., Piveteau, C., Mathys, V., Flament, M.-P., Siepmann, J., Villeret, V., Wohlkönig, A., Wintjens, R., Soror, S. H., Christophe, T., Jeon, H. K., Locht, C., Brodin, P., Deprez, B., Baulard, A. R., & Willand, N. Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors. Journal of Medicinal Chemistry,2012, 55(1): 68-83 doi:10.1021/jm200825u
  • Aknin, K., Gauriot, M., Totobenazara, J., Deguine, N., Deprez-Poulain, R., Deprez, B., & Charton, J. Squaric acid is a suitable building-block in 4C-Ugi reaction: access to original bivalent compounds. Tetrahedron Letters,2012, 53(4): 458-461 doi:10.1016/j.tetlet.2011.11.077

2011

  • Mesangeau, C., Fraise, M., Delagrange, P., Caignard, D. H., Boutin, J. A., Berthelot, P., & Yous, S. Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands. Eur J Med Chem,2011, 46(5):1835-1840 doi:10.1016/j.ejmech.2011.02.044
  • Pellegrini, S., Grad, J.-N., Bousquet, T., & Pelinski, L. A novel multicomponent reaction: easy access to ferrocenyl (alkylimino)-1,4-dihydroquinolines. Tetrahedron Letters,2011, 52(15):1742 doi:10.1016/j.tetlet.2011.01.144
  • Mwande-Maguene, G., Jakhlal, J., Lekana-Douki, J.-B., Mouray, E., Bousquet, T., Pellegrini, S., Grellier, P., Ndouo, F. S. T., Lebibi, J., & Pelinski, L. One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines. New Journal of Chemistry,2011, 35(11):2412 doi:10.1039/C1NJ20551J
  • Andrzejak, V., Muccioli, G. G., Body-Malapel, M., El Bakali, J., Djouina, M., Renault, N., Chavatte, P., Desreumaux, P., Lambert, D. M., & Millet, R. g. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. Bioorganic & Medicinal Chemistry,2011, 19(12):3777-3786 doi:10.1016/j.bmc.2011.04.057
  • Hadjaz, F., Besret, S., Martin-Nizard, F., Yous, S., Dilly, S., Lebegue, N., Chavatte, P., Duriez, P., Berthelot, P., & Carato, P. Antioxydant activity of beta-carboline derivatives in the LDL oxidation model. Eur J Med Chem,2011, 46(6): 2575-2585 doi:10.1016/j.ejmech.2011.03.048
  • Andrzejak, V., Muccioli, G. G., Body-Malapel, M., El Bakali, J., Djouina, M., Renault, N., Chavatte, P., Desreumaux, P., Lambert, D. M., & Millet, R. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. Bioorganic & Medicinal Chemistry,2011, 19(12): 3777–3786 doi:10.1016/j.bmc.2011.04.057
  • Maguene, G. M., Jakhlal, J., Ladyman, M., Vallin, A., Ralambomanana, D. A., Bousquet, T., Maugein, J., Lebibi, J., & Pélinski, L. Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives. European Journal of Medicinal Chemistry,2011, 46(1): 31 doi:10.1016/j.ejmech.2010.10.004
  • Leclerc, V., Ettaoussi, M., Rami, M., Farce, A., Boutin, J. A., Delagrange, P., Caignard, D. H., Renard, P., Berthelot, P., & Yous, S. Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3. Eur J Med Chem,2011, 46(5): 1622-1629 doi:10.1016/j.ejmech.2011.02.010
  • Keldenich, J. r. m., Michon, C., Nowicki, A., & Agbossou-Niedercorn, F. Synthesis of a Chiral Key Intermediate of Neurokinin Antagonist SSR 240600 by Asymmetric Allylic Alkylation. Synlett,2011, 2011(EFirst): 2939,2942 doi:10.1055/s-0031-1289878
  • Lino Cardenas, C. L., Renault, N., Farce, A., Cauffiez, C., Allorge, D., Lo-Guidice, J. M., Lhermitte, M., Chavatte, P., Broly, F., & Chevalier, D. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. Gene,2011, 487(1): 10-20 doi:10.1016/j.gene.2011.07.015
  • Jida, M., Soueidan, M., Willand, N., Agbossou-Niedercorn, F., Pelinski, L., Laconde, G., Deprez-Poulain, R., & Deprez, B. A facile and rapid synthesis of N-benzyl-2-substituted piperazines. Tetrahedron Letters,2011, 52(14): 1705-1708 doi:10.1016/j.tetlet.2011.02.011
  • Liberge, G., Lebrun, S., Couture, A., & Grandclaudon, P. A Convenient Synthesis of Functionalized α-Methylidenebutano-4-lactams. Helvetica Chimica Acta,2011, 94(9): 1662-1670 doi:10.1002/hlca.201100070
  • Liberge, G., Lebrun, S., Couture, A., & Grandclaudon, P. Techniques d'assemblage de systèmes bislactones, poly et diversement substitués. Comptes Rendus Chimie,2011, 14(11): 1014-1021 doi:10.1016/j.crci.2011.07.004
  • Liberge, G., Lebrun, S., Couture, A., & Grandclaudon, P. Approche synthétique efficace pour l'assemblage d'éthylène-butyrolactones diversement fonctionnalisées. Comptes Rendus Chimie,2011, 14(10): 916-926 doi:10.1016/j.crci.2011.03.006
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Ring-Closing Metathesis Approach to 2H-2-Benzazepine-1,3-diones. Synthesis,2011, 2011(04) doi:10.1055/s-0030-1258416
  • Lebrun, S., Couture, A., Deniau, E., & Grandclaudon, P. Suzuki-Miyaura cross-coupling and ring-closing metathesis: a strategic combination to the synthesis of indeno[1,2-c]isoquinolin-5,11-diones. Tetrahedron Letters,2011, 52(13): 1481-1484 doi:10.1016/j.tetlet.2011.01.113
  • Ahn, G., Schifano-Faux, N., Goossens, J.-F., Baldeyrou, B., Couture, A., Grandclaudon, P., Lansiaux, A., & Ryckebusch, A. Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones. Bioorganic and Medicinal Chemistry Letters,2011, 21(8): 2259-2263 doi:10.1016/j.bmcl.2011.02.106
  • Ahn, G., Lorion, M., Agouridas, V., Couture, A., Deniau, E., & Grandclaudon, P. A Concise and Flexible Diastereoselective Approach to Heteroring-Fused Isoindolinones. Synthesis,2011, 2011(01) doi:10.1055/s-0030-1258313
  • Agouridas, V., Capet, F., Couture, A., Deniau, E., & Grandclaudon, P. A highly diastereoselective synthesis of isoindolinone-centered Meyers' tetracyclic lactams. Application to the asymmetric synthesis of 3-alkylisoindolinones. Tetrahedron: Asymmetry,2011, 22(13): 1441-1447 doi:10.1016/j.tetasy.2011.07.020
  • Le Fur, N., Hochart, G., Larchanché, P.-E., & Melnyk, P. Buchwald reaction as the key step for the synthesis of metabolically more stable analogs of amodiaquine. European Journal of Medicinal Chemistry,2011, 46(7): 3052-3057 doi:10.1016/j.ejmech.2011.04.047
  • Cabordery, A.-C., Toussaint, M., Azaroual, N., Bonte, J.-P., Melnyk, P., Vaccher, C., & Foulon, C. Kinetics and mechanism of racemization of Tic-hydantoins, potent sigma-1 agonists. Tetrahedron: Asymmetry,2011, 22(2): 125-133 doi:10.1016/j.tetasy.2011.01.015
  • Sengupta, S., Vasconcelos, F., Affouard, F., & Sastry, S. Dependence of the fragility of a glass former on the softness of interparticle interactions. Journal of Chemical Physics,2011, 135: 194503 doi:10.1063/1.3660201
  • Lerbret, A., Affouard, F., Bordat, P., Hédoux, A., Guinet, Y., & Descamps, M. Slowing down of water dynamics in disaccharide aqueous solutions. Journal of Non-Crystalline Solids,2011, 357(2): 695-699 doi:10.1016/j.jnoncrysol.2010.05
  • Dujardin, N., Dudognon, E., Willart, J. F., Hédoux, A., Guinet, Y., Paccou, L., & Descamps, M. Solid State Mutarotation of Glucose. The Journal of Physical Chemistry B,2011, 115(7): 1698-1705 doi:10.1021/jp109382j
  • Tabary, N., Mahieu, A. l., Willart, J.-F. o., Dudognon, E., Danède, F., Descamps, M., Bacquet, M., & Martel, B. Characterization of the hidden glass transition of amorphous cyclomaltoheptaose. Carbohydrate Research,2011, 346(14): 2193-2199 doi:10.1016/j.carres.2011.07.010
  • Hedoux, A., Guinet, Y., & Descamps, M. The contribution of Raman spectroscopy to the analysis of phase transformations in pharmaceutical compounds. International Journal of Pharmaceutics,2011, 417(1-2): 17-31 doi:10.1016/j.ijpharm.2011.01.031
  • Hedoux, A., Decroix, A.-A., Guinet, Y., Paccou, L., Derollez, P., & Descamps, M. Low- and High-Frequency Raman Investigations on Caffeine: Polymorphism, Disorder and Phase Transformation. The Journal of Physical Chemistry B,2011, 115(19): 5746-5753 doi:10.1021/jp112074w
  • Caron, V., Willart, J.-F. o., Lefort, R., Derollez, P., Danède, F., & Descamps, M. Solid state amorphization kinetic of alpha lactose upon mechanical milling. Carbohydrate Research,2011, 346(16): 2622-2628 doi:10.1016/j.carres.2011.09.004
  • Kreye, F., Siepmann, F., Zimmer, A., Willart, J. F., Descamps, M., & Siepmann, J. Controlled release implants based on cast lipid blends. European Journal of Pharmaceutical Sciences,2011, 43(1-2): 78-83 doi:10.1016/j.ejps.2011.03.013
  • Kreye, F., Siepmann, F., Willart, J. F., Descamps, M., & Siepmann, J. Drug release mechanisms of cast lipid implants. European Journal of Pharmaceutics and Biopharmaceutics,2011, 78(3): 394-400 doi:10.1016/j.ejpb.2011.02.011
  • Kreye, F., Siepmann, F., Zimmer, A., Willart, J.-F., Descamps, M., & Siepmann, J. Cast lipid implants for controlled drug delivery: Importance of the tempering conditions. Journal of Pharmaceutical Sciences,2011, 100(8): 3471-3481 doi: 10.1002/jps.22574
  • Busselez, R., Lefort, R., Ghoufi, A., Beuneu, B., Frick, B., Affouard, F., & Morineau, D. The non-Gaussian dynamics of glycerol. Journal of Physics: Condensed Matter,2011, 23(50): 505102 doi:10.1088/0953-8984/23/50/505102
  • Stern, E., Goossens, L., Retailleau, P., Kauffmann, B., Bonte, J. P., Depreux, P., & Goossens, J. F. Preparative enantiomeric separation of new selective CB2 receptor agonists by liquid chromatography on polysaccharide-based chiral stationary phases: determination of enantiomeric purity and assignment of absolute stereochemistry by X-ray structure analysis. Chirality,2011, 23(5): 389-396 doi:10.1002/chir.20939
  • Queruau-Lamerie, T., Carrez, L., Decaudin, B., Bouchoud, L., Goossens, J. F., Barthelemy, C., Bonnabry, P., & Odou, P. Multiple-test assessment of devices to protect healthcare workers when administering cytotoxic drugs to patients. J Oncol Pharm Pract,2011: in press doi:10.1177/1078155211416531
  • Lecoeur, M., Goossens, J. F., Vaccher, C., Bonte, J. P., & Foulon, C. A multivariate approach for the determination of isoelectric point of human carbonic anhydrase isoforms by capillary isoelectric focusing. Electrophoresis,2011, 32(20): 2857-2866 doi:10.1002/elps.201100219
  • Danel, C., Duval, C., Azaroual, N., Vaccher, C., Bonte, J. P., Bailly, C., Landy, D., & Goossens, J. F. Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies. J Chromatogr A,2011, 1218(48): 8708-8714 doi:10.1016/j.chroma.2011.10.007
  • Lecoeur, M., Verones, V., Vaccher, C., Bonte, J. P., Lebegue, N., & Goossens, J. F. Structural elucidation of degradation products of a benzopyridooxathiazepine under stress conditions using electrospray orbitrap mass spectrometry - Study of degradation kinetic. Eur J Pharm Sci,2011 doi:10.1016/j.ejps.2011.12.009
  • Gosselet, F., Candela, P., Cecchelli, R., & Fenart, L. Role of the blood-brain barrier in Alzheimer's disease. Med Sci (Paris),2011, 27(11): 987-992 doi:10.1051/medsci/20112711015
  • Liang, Z., Zhang, L., Li, L., Liu, J., Li, H., Zhang, L., Chen, L., Cheng, K., Zheng, M., Wen, X., Zhang, P., Hao, J., Gong, Y., Zhang, X., Zhu, X., Chen, J., Liu, H., Jiang, H., Luo, C., & Sun, H. Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. European Journal of Medicinal Chemistry,2011, 46(6): 2011-2021 doi:10.1016/j.ejmech.2011.02.053
  • Carette, X., Blondiaux, N., Willery, E., Hoos, S., Lecat-Guillet, N., Lens, Z., Wohlkonig, A., Wintjens, R., Soror, S., Frenois, F., Dirié, B., Villeret, V., England, P., Lippens, G., Deprez, B., Locht, C., Willand, N., & Baulard, A. Structural activation of the transcriptional repressor EthR from M.tuberculosis by single amino-acid change mimicking natural and synthetic ligands. Nucleic Acids Res,2011: in press doi: 10.1093/nar/gkr1113
  • Soueidan, M., Jida, M., Bousquet, T., Niedercorn, F. A., & Pelinski, L. Efficient access to new chiral ferrocenyl [gamma]-lactams from amino alcohols. New Journal of Chemistry,2011, 35(5): 991-993 doi: 10.1039/C1NJ20059C
  • Deprez-Poulain, R., Cousaert, N., Toto, P., Willand, N., & Deprez, B. Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation. Eur J Med Chem,2011, 46: 3867-3876 doi:10.1016/j.ejmech.2011.05.056
  • Bonnel, D., Legouffe, R., Willand, N., Baulard, A., Hamm, G., Deprez, B., & Stauber, J. MALDI imaging techniques dedicated to drug-distribution studies. Bioanalysis,2011, 3(12): 1399-1406 doi: 10.4155/bio.11.88
  • Flipo, M., Desroses, M., Lecat-Guillet, N., Dirié, B., Carette, X., Leroux, F., Piveteau, C., Demirkaya, F., Lens, Z., Rucktooa, P., Villeret, V., Christophe, T., Jeon, H. K., Locht, C., Brodin, P., Déprez, B., Baulard, A. R., & Willand, N. Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors. Journal of Medicinal Chemistry,2011, 54(8): 2994-3010 doi:10.1021/jm200076a 
  • Beghyn, T. B., Charton, J., Leroux, F., Laconde, G., Bourin, A., Cos, P., Maes, L., & Deprez, B. Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds. Journal of Medicinal Chemistry,2011, 54(9): 3222–3240 doi:10.1021/jm1014617
  • Zhang, B., Corbel, C., Gueritte, F., Couturier, C., Bach, S., & Tan, V. An in silico approach for the discovery of CDK5/p25 interaction inhibitors. Biotechnol J.,2011, 6(7): 871-881 doi:10.1002/biot.201100139

2010

  • El Bakali, J., Muccioli, G. G., Renault, N., Pradal, D., Body-Malapel, M., Djouina, M., Hamtiaux, L., Andrzejak, V., Desreumaux, P., Chavatte, P., Lambert, D. M., & Millet, R. g. 4-Oxo-1,4-dihydropyridines as Selective CB2 Cannabinoid Receptor Ligands: Structural Insights into the Design of a Novel Inverse Agonist Series. Journal of Medicinal Chemistry,2010, 53(22): 7918-7931 doi:10.1021/jm100286k
  • Peyrin-Biroulet, L., Beisner, J., Wang, G., Nuding, S., Oommen, S. T., Kelly, D., Parmentier-Decrucq, E., Dessein, R., Merour, E., Chavatte, P., Grandjean, T., Bressenot, A., Desreumaux, P., Colombel, J. F., Desvergne, B., Stange, E. F., Wehkamp, J., & Chamaillard, M. Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A,2010, 107(19): 8772-8777 doi:10.1073/pnas.0905745107
  • Renault, N., Gohier, A., Chavatte, P., & Farce, A. Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model. Eur J Med Chem,2010, 45(11): 5086-5099 doi:10.1016/j.ejmech.2010.08.018
  • Verones, V., Flouquet, N., Farce, A., Carato, P., Leonce, S., Pfeiffer, B., Berthelot, P., & Lebegue, N. Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives. Eur J Med Chem,2010, 45(12): 5678-5684 doi:10.1016/j.ejmech.2010.09.022
  • Maj, A. M., Suisse, I., Méliet, C., & Agbossou-Niedercorn, F. Enantioselective hydrogenation of indoles derivatives catalyzed by Walphos/rhodium complexes. Tetrahedron: Asymmetry,2010, 21(16): 2010-2014 doi:10.1016/j.tetasy.2010.06.030
  • Michon, C., Medina, F., Capet, F., Roussel, P., & Agbossou-Niedercorn, F. Inter- and Intramolecular Hydroamination of Unactivated Alkenes Catalysed by a Combination of Copper and Silver Salts: The Unveiling of a Brønstedt Acid Catalysis. Advanced Synthesis & Catalysis,2010, 352(18): 3293
  • Kouakou-Siransy, G., Sahpaz, S., Nguessan, G. I., Datte, J. Y., Brou, J. K., Gressier, B., & Bailleul, F. Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils. Pharm Biol,2010, 48(2): 128-133 doi:10.3109/13880200903051609
  • Roumy, V., Biabiany, M., Hennebelle, T., Aliouat el, M., Pottier, M., Joseph, H., Joha, S., Quesnel, B., Alkhatib, R., Sahpaz, S., & Bailleul, F. Antifungal and cytotoxic activity of withanolides from Acnistus arborescens. J Nat Prod,2010, 73(7): 1313-1317 doi:10.1021/np100201p
  • Alkhatib, R., Hennebelle, T., Joha, S., Roumy, V., Guzel, Y., Biabiany, M., Idziorek, T., Preudhomme, C., Quesnel, B., Sahpaz, S., & Bailleul, F. Humulane and germacrane sesquiterpenes from Ferula lycia. J Nat Prod,2010, 73(4): 780-783 doi:10.1021/np900827a
  • Alkhatib, R., Joha, S., Cheok, M., Roumy, V., Idziorek, T., Preudhomme, C., Quesnel, B., Sahpaz, S., Bailleul, F., & Hennebelle, T. Activity of ladanein on leukemia cell lines and its occurrence in Marrubium vulgare. Planta Med,2010, 76(1): 86-87 doi:10.1055/s-0029-1185972
  • Lorion, M., Agouridas, V., Couture, A., Deniau, E., & Grandclaudon, P. Synthesis and cytotoxic evaluation of cis-locked and constrained analogues of combretastatin and combretastatin A4. Tetrahedron Letters,2010, 51(39): 5146-5149 doi:10.1016/j.tetlet.2010.07.120
  • Lorion, M., Agouridas, V., Couture, A., Deniau, E., & Grandclaudon, P. Cyclic Sulfamidates as Vehicles for the Synthesis of Poly- and Diversely Substituted Benzosultams via Unusual S(O)2−O Bond Cleavage. Organic Letters,2010, 12(6): 1356–1359 doi: 10.1021/ol100288k
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Ring-Closing Metathesis Approach to 2H-2-Benzazepine-1,3-diones. Synthesis,2010, 2011(04): 669-673 doi:10.1055/s-0030-1258416
  • Dumoulin, D., Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. First asymmetric synthesis of (un)substituted bridged tetrahydro-2-benzazepiDumoulin, D., Lebrun, S., Couture, A., Deniau, E., & Grandclaudon, P. Asymmetric synthesis of trans-3,4-disubstituted tetrahydro-2-benzazepines. ARKIVOC,2010: 195 - 204nes. Tetrahedron: Asymmetry,2010, 21(2): 195-201 doi:10.1016/j.tetasy.2009.12.026
  • Dumoulin, D., Lebrun, S., Couture, A., Deniau, E., & Grandclaudon, P. First Asymmetric Synthesis of Boehmeriasin A. European Journal of Organic Chemistry,2010, 2010(10): 1943-1950 doi:10.1002/ejoc.200901404
  • Ahn, G., Lorion, M., Agouridas, V., Couture, A., Deniau, E., & Grandclaudon, P. A Concise and Flexible Diastereoselective Approach to Heteroring-Fused Isoindolinones. Synthesis,2010, 2011(01): 147-153 doi:10.1055/s-0030-1258313
  • Ahn, G., Lansiaux, A. l., Goossens, J.-F. o., Bailly, C., Baldeyrou, B., Schifano-Faux, N. g., Grandclaudon, P., Couture, A., & Ryckebusch, A. Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties. Bioorganic & Medicinal Chemistry,2010, 18(22): 8119-8133 doi:10.1016/j.bmc.2010.08.025
  • Toussaint, M., Debreu-Fontaine, M. A., Maurice, T., & Melnyk, P. New Synthesis of Tic-Hydantoins Sigma-1 Ligands and Pharmacological Evaluation on Cocaine-Induced Stimulant Effects. Medicinal Chemistry,2010, 6(6): 355-373 doi:10.2174/157340610793563956
  • Toussaint, M., Mousset, D., Foulon, C., Jacquemard, U., Vaccher, C., & Melnyk, P. Sigma-1 ligands: Tic-hydantoin as a key pharmacophore. European Journal of Medicinal Chemistry,2010, 45(1): 256-263 doi:10.1016/j.ejmech.2009.10.004
  • Le Fur, N., Larchanche, P.-E., & Melnyk, P. Optimized and convergent synthesis of potent anti-malarial aminoquinoline compounds: easy access to analogs. Heterocyclic communications,2010, 16(4-6): 235-239 doi:10.1515/HC.2010.011
  • Laurette, S., Treizebre, A., Affouard, F., & Bocquet, B. Subterahertz characterization of ethanol hydration layers by microfluidic system. Applied Physics Letters,2010, 97: 111904 doi:10.1063/1.3488832
  • Magazù, S., Migliardo, F., Affouard, F., Descamps, M., & Telling, M. T. F. Study of the relaxational and vibrational dynamics of bioprotectant glass-forming mixtures by neutron scattering and molecular dynamics simulation. Journal of Chemical Physics,2010, 132: 184512 doi:10.1063/1.3407428
  • Seo, J.-A., Hédoux, A., Guinet, Y., Paccou, L., Affouard, F. d. r., Lerbret, A., & Descamps, M. Thermal Denaturation of Beta-Lactoglobulin and Stabilization Mechanism by Trehalose Analyzed from Raman Spectroscopy Investigations. The Journal of Physical Chemistry B,2010, 114(19): 6675-6684 doi:10.1021/jp1006022
  • Affouard, F., & Correia, N. l. T. Debye Process in Ibuprofen Glass-Forming Liquid: Insights from Molecular Dynamics Simulation. The Journal of Physical Chemistry B,2010, 114(35): 11397-11402 doi:10.1021/jp1046358
  • Willart, J. F., Dujardin, N., Dudognon, E., Danède, F., & Descamps, M. Amorphization of sugar hydrates upon milling. Carbohydrate Research,2010, 345(11): 1613-1616 doi:10.1016/j.carres.2010.04.014
  • Mesangeau, C., Peres, B., Descamps-Francois, C., Chavatte, P., Audinot, V., Coumailleau, S., Boutin, J. A., Delagrange, P., Bennejean, C., Renard, P., Caignard, D. H., Berthelot, P., & Yous, S. Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem,2010, 18(10): 3426-3436 doi:10.1016/j.bmc.2010.04.008
  • Garofalo, A., Goossens, L., Baldeyrou, B., Lemoine, A., Ravez, S., Six, P., David-Cordonnier, M. H., Bonte, J. P., Depreux, P., Lansiaux, A., & Goossens, J. F. Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives. J Med Chem,2010, 53(22): 8089-8103 doi:10.1021/jm1009605
  • Klose, D., Delplace, C., & Siepmann, J. Unintended potential impact of perfect sink conditions on PLGA degradation in microparticles. International Journal of Pharmaceutics,2010, 404(1-2): 75-82.doi:10.1016/j.ijpharm.2010.10.054
  • Kreye, F., Siepmann, F., & Siepmann, J. Drug release mechanisms of compressed lipid implants. International Journal of Pharmaceutics,2010, 404(1-2): 27-35 doi:10.1016/j.ijpharm.2010.10.048
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L., Flament, M. P., Dubreuil, L., Desreumaux, P., & Siepmann, J. Peas starch-based film coatings for site-specific drug delivery to the colon. Journal of Applied Polymer Science,2010, 119(2): 1176-1184 doi:10.1002/app.32802
  • Blanchemain, N., Karrout, Y., Tabary, N., Neut, C., Bria, M., Siepmann, J., Hildebrand, H. F., & Martel, B. Methyl-b-cyclodextrin modified vascular prosthesis: Influence of the modification level on the drug delivery properties in different media. Acta Biomaterialia,2010, 7(1): 304-314 doi:10.1016/j.actbio.2010.09.002
  • Hedoux, A., Krenzlin, S., Paccou, L., Guinet, Y., Flament, M.-P., & Siepmann, J. Influence of urea and guanidine hydrochloride on lysozyme stability and thermal denaturation; a correlation between activity, protein dynamics and conformational changes. Physical Chemistry Chemical Physics,2010, 12(40): 13189-13196 doi:10.1039/C0CP00602E
  • Karrout, Y., Neut, C., Siepmann, F., Wils, D., Ravaux, P., Deremaux, L., Flament, M. P., Dubreuil, L., Lemdani, M., Desreumaux, P., & Siepmann, J. Enzymatically degraded Eurylon 6 HP-PG: ethylcellulose film coatings for colon targeting in inflammatory bowel disease patients. Journal of Pharmacy and Pharmacology,2010, 62(12): 1676-1684 doi:10.1111/j.2042-7158.2010.01165.x
  • Hoang Thi, T. H., Chai, F., Leprêtre, S., Blanchemain, N., Martel, B., Siepmann, F., Hildebrand, H. F., Siepmann, J., & Flament, M. P. Bone implants modified with cyclodextrin: Study of drug release in bulk fluid and into agarose gel. International Journal of Pharmaceutics,2010, 400(1-2): 74-85 doi:10.1016/j.ijpharm.2010.08.035
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L., Flament, M.-P., Dubreuil, L., Desreumaux, P., & Siepmann, J. Enzymatically activated coated multiparticulates containing theophylline for colon targeting. Journal of Drug Delivery Science and Technology,2010, 20(3): 193-199
  • Muschert, S., Siepmann, F., Leclercq, B., Carlin, B., & Siepmann, J. Simulated food effects on drug release from ethylcellulose: PVA–PEG graft copolymer-coated pellets. Drug Development and Industrial Pharmacy,2010, 36(2): 173-179 doi:10.3109/03639040903200706
  • Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. Mathematical modeling of drug release from Eudragit RS-based delivery systems. Journal of Drug Delivery Science and Technology,2010, 20(2): 127-133
  • Glaessl, B., Siepmann, F., Tucker, I., Rades, T., & Siepmann, J. Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International Journal of Pharmaceutics,2010, 389(1-2): 139-146 doi:10.1016/j.ijpharm.2010.01.031
  • Klose, D., Siepmann, F., Willart, J. F., Descamps, M., & Siepmann, J. Drug release from PLGA-based microparticles: Effects of the “microparticle:bulk fluid” ratio. International Journal of Pharmaceutics,2010, 383(1-2): 123-131 doi:10.1016/j.ijpharm.2009.09.012
  • Willand, N., Desroses, M., Toto, P., Dirie, B., Lens, Z., Villeret, V., Rucktooa, P., Locht, C., Baulard, A., & Deprez, B. Exploring Drug Target Flexibility Using in Situ Click Chemistry: Application to a Mycobacterial Transcriptional Regulator. ACS Chemical Biology,2010, 5(11): 1007 doi:10.1021/cb100177g
  • Maingot, L., Leroux, F., Landry, V., Dumont, J., Nagase, H., Villoutreix, B., Sperandio, O., Deprez-Poulain, R., & Deprez, B. New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. Bioorganic & Medicinal Chemistry Letters,2010, 21: 6213-6216 doi:10.1016/j.bmcl.2010.08.108
  • Jida, M., Malaquin, S., Deprez-Poulain, R., Laconde, G., & Deprez, B. Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction. Tetrahedron Letters,2010, 51(39): 5109-5111 doi:10.1016/j.tetlet.2010.07.021
  • Lipka, E., Folly-Klana, M., Charton, J., Vaccher, M.-P., Bonte, J.-P., & Vaccher, C. Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis,2010, 53: 1267-1271 doi:10.1016/j.jpba.2010.07.023
  • Malaquin, S., Jida, M., Gesquiere, J.-C., Deprez-Poulain, R., Deprez, B., & Laconde, G. Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil. Tetrahedron Letters,2010, 51(22): 2983-2985 doi:10.1016/j.tetlet.2010.03.120
  • Jida, M., Deprez-Poulain, R., Malaquin, S., Roussel, P., Agbossou-Niedercorn, F., Deprez, B., & Laconde, G. Solvent-free microwave-assisted Meyers’ lactamization. Green Chemistry,2010, 12: 961-964 doi:10.1039/B924111F
  • Reynes, C., Host, H., Camproux, A.-C., Laconde, G., Leroux, F., Mazars, A., Deprez, B., Fahraeus, R., Villoutreix, B. O., & Sperandio, O. Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods. Plos Computational Biology,2010, 6(3): e1000695 doi:10.1371/journal.pcbi.1000695
  • Siepmann, F., Eckart, K., Maschke, A., Kolter, K., & Siepmann, J. Modeling drug release from PVAc/PVP matrix tablets. Journal of Controlled Release,2010, 141(2): 216-222 doi:10.1016/j.jconrel.2009.08.027
  • Yang, Q. W., Flament, M. P., Siepmann, F., Busignies, V., Leclerc, B., Herry, C., Tchoreloff, P., & Siepmann, J. Curing of aqueous polymeric film coatings: Importance of the coating level and type of plasticizer. European Journal of Pharmaceutics and Biopharmaceutics,2010, 74(2): 362-370 doi:10.1016/j.ejpb.2009.10.007
  • Lipka, E., Folly-Klan, M., Charton, J., Vaccher, M.-P., Bonte, J.-P., & Vaccher, C. Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis,2010, 53(5): 1267-1271 doi:10.1016/j.jpba.2010.07.023
  • Cabordery, A. C., Toussaint, M., Bonte, J. P., Melnyk, P., Vaccher, C., & Foulon, C. Separation of Tic-hydantoin enantiomers, potent sigma-1 agonists, by high performance liquid chromatography and capillary electrophoresis. Journal of Chromatography A,2010, 1217(24): 3871-3875 doi:10.1016/j.chroma.2010.04.009
  • Lipka, E., Danel, C., Yous, S., Bonte, J.-P., & Vaccher, C. Dual CD system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoninergic ligands. Electrophoresis,2010, 31(9): 1529-1532 doi:10.1002/elps.200900661
  • Lipka, E., Vaccher, M.-P., Vaccher, C., & Bonte, J.-P. Chiral Capillary Electrophoresis with Highly Sulfated Cyclodextrins; Resolution of Benzoxazolinone Aminoalcohols, and Aminoketon Precursors, Potential Adrenergic Ligands. Analytical Letters,2010, 43(15): 2356-2371 doi:10.1080/00032711003717448
  • Garofalo, A., Goossens, L., Lemoine, A., Farce, A., Arlot, Y., & Depreux, P. Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer. J Enzyme Inhib Med Chem,2010, 25(2): 158-171 doi:10.3109/14756360903169485
  • El Bakali, J., Muccioli, G. G., Renault, N., Pradal, D., Body-Malapel, M., Djouina, M., Hamtiaux, L., Andrzejak, V., Desreumaux, P., Chavatte, P., Lambert, D. M., & Millet, R. 4-Oxo-1,4-dihydropyridines as Selective CB2 Cannabinoid Receptor Ligands: Structural Insights into the Design of a Novel Inverse Agonist Series. Journal of Medicinal Chemistry,2010, 53(22): 7918–7931 doi:10.1021/jm100286k
  • Gluszok, S., Frederick, R., Foulon, C., Klupsch, F., Supuran, C. T., Vullo, D., Scozzafava, A., Goossens, J.-F., Masereel, B., Depreux, P., & Goossens, L. Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors. Bioorganic and Medicinal Chemistry,2010, 18(21): 7392-7401 doi:10.1016/j.bmc.2010.09.007

2009

  • Farce, A., Renault, N., & Chavatte, P. Structural insight into PPARgamma ligands binding. Curr Med Chem,2009, 16(14): 1768-1789, doi:10.2174/092986709788186165
  • El Bakali, J., Klupsch, F., Guedin, A., Brassart, B., Fontaine, G., Farce, A., Roussel, P., Houssin, R., Bernier, J. L., Chavatte, P., Mergny, J. L., Riou, J. F., & Henichart, J. P. 2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers. Bioorg Med Chem Lett,2009, 19(13): 3434-3438 doi.org/10.1016/j.bmcl.2009.05.025
  • Yekini, I., Hammoudi, F., Martin-Nizard, F., Yous, S., Lebegue, N., Berthelot, P., & Carato, P. Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model. Bioorg Med Chem,2009, 17(22): 7823-7830 doi:10.1016/j.bmc.2009.09.016
  • Durieux, S., Chanu, A., Bochu, C., Audinot, V., Coumailleau, S., Boutin, J. A., Delagrange, P., Caignard, D. H., Bennejean, C., Renard, P., Lesieur, D., Berthelot, P., & Yous, S. Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II. Bioorg Med Chem,2009, 17(8): 2963-2974.doi.org/10.1016/j.bmc.2009.03.023,
  • Gallet, S., Flouquet, N., Carato, P., Pfeiffer, B., Renard, P., Leonce, S., Pierre, A., Berthelot, P., & Lebegue, N. Benzopyridooxathiazepine derivatives as novel potent antimitotic agents. Bioorg Med Chem,2009, 17(3): 1132-1138.doi.org/10.1016/j.bmc.2008.12.039,
  • Hennebelle, T., Weniger, B., Joseph, H., Sahpaz, S., & Bailleul, F. Senna alata. Fitoterapia,2009, 80(7): 385-393.dx.doi.org/10.1016/j.fitote.2009.05.008,
  • Zamble, A., Martin-Nizard, F., Sahpaz, S., Reynaert, M. L., Staels, B., Bordet, R., Duriez, P., Gressier, B., & Bailleul, F. Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction. Phytother Res,2009, 23(6): 892-895.DOI: 10.1002/ptr.2717
  • Lorion, M., Couture, A., Deniau, E., & Grandclaudon, P. Complementary Synthetic Approaches to Constitutionally Diverse N-Aminoalkylated Isoindolinones: Application to the Synthesis of Falipamil and 5-HT1A Receptor Ligand Analogues. Synthesis,2009, 2009(EFirst): 1897-1903.doi: 10.1055/s-0028-1088048
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. A Practical Photochemically Induced Method for N-N Bond Cleavage of N,N-Disubstituted Hydrazides. Synlett,2009, 2009(EFirst): 2621-2624.doi: 10.1055/s-0029-1217759
  • Lebrun, S., Couture, A., Deniau, E., & Grandclaudon, P. Stereoselective asymmetric synthesis of (+)-sedamine and (+)-allosedamine. Chirality,2009, 22(2): 212-216.DOI: 10.1002/chir.20729
  • Dumoulin, D., Lebrun, S., Deniau, E., Couture, A., & Grandclaudon, P. First Asymmetric Synthesis of (Un)saturated 1-Alkylbenzo[c]azepin-3-ones: Extension to the Corresponding Benzazepines. European Journal of Organic Chemistry,2009, 2009(22): 3741-3752.doi: 10.1002/ejoc.200900365
  • Barras, A., Mezzetti, A., Richard, A., Lazzaroni, S., Roux, S., Melnyk, P., Betbeder, D., & Monfilliette-Dupont, N. Formulation and characterization of polyphenol-loaded lipid nanocapsules. International Journal of Pharmaceutics,2009, 379(2): 270-277.doi:10.1016/j.ijpharm.2009.05.054
  • Toussaint, M., Delair, B., Foulon, C., Lempereur, N. g., Vaccher, C., Maurice, T., & Melnyk, P. Tic hydantoin sigma-1 agonist: Pharmacological characterization on cocaine-induced stimulant and appetitive effects. European Neuropsychopharmacology,2009, 19(7): 504-515.doi:10.1016/j.euroneuro.2009.01.008
  • Paunescu, E., Susplugas, S., Boll, E., Varga, R., Mouray, E., Grosu, I., Grellier, P., & Melnyk, P. Replacement of the 4′-Hydroxy Group of Amodiaquine and Amopyroquine by Aromatic and Aliphatic Substituents: Synthesis and Antimalarial Activity. ChemMedChem,2009, 4(4): 549-561.DOI: 10.1002/cmdc.200800318
  • Lerbret, A., Affouard, F., Bordat, P., Hédoux, A., Guinet, Y., & Descamps, M. Low-frequency vibrational properties of lysozyme in sugar aqueous solutions: a Raman scattering and molecular dynamics simulation study. Journal of Chemical Physics,2009, 131: 245103.doi: 10.1063/1.3273218
  • Affouard, F., Descamps, M., Valdes, L. C., Habasaki, J., Bordat, P., & Ngai, K. L. Breakdown of the Stokes-Einstein relation in Lennard-Jones glassforming mixtures with interaction potential. Journal of Chemical Physics,2009, 131: 104510.doi: 10.1063/1.3204063
  • Valdes, L. C., Affouard, F., Descamps, M., & Habasaki, J. Mixing effects in glass-forming Lennard-Jones mixtures. Journal of Chemical Physics,2009, 130: 154505.doi: 10.1063/1.3106759
  • Hedoux, A., Willart, J.-F., Paccou, L., Guinet, Y., Affouard, F., Lerbret, A., & Descamps, M. Thermostabilization Mechanism of Bovine Serum Albumin by Trehalose. The Journal of Physical Chemistry B,2009, 113(17): 6119-6126.doi: 10.1021/jp900330r
  • Busselez, R., Lefort, R., Ji, Q., Affouard, F., & Morineau, D. Molecular dynamics simulation of nanoconfined glycerol. Physical Chemistry Chemical Physics,2009, 11(47): 11127-11133.doi: 10.1039/B911859D
  •  
  • Hedoux, A., Paccou, L., Guinet, Y., Willart, J.-F. o., & Descamps, M. Using the low-frequency Raman spectroscopy to analyze the crystallization of amorphous indomethacin. European Journal of Pharmaceutical Sciences,2009, 38(2): 156-164.doi:10.1016/j.ejps.2009.06.007
  • Dujardin, N., Willart, J. F., Dudognon, E., Danède, F., & Descamps, M. First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration. Journal of Pharmaceutical Sciences,2009, 99(3): 1476-1483.doi: 10.1002/jps.21900
  • Foulon, C., Tedou, J., Peyrottes, S., Perigaud, C., Bonte, J. P., Vaccher, C., & Goossens, J. F. Separation of diastereoisomers of Ara-C phosphotriesters using solid phase extraction and HPLC for the study of their decomposition kinetic in cell extracts. J Chromatogr B Analyt Technol Biomed Life Sci,2009, 877(29): 3475-3481.dx.doi.org/10.1016/j.jchromb.2009.08.004
  • Gosselet, F., Candela, P., Sevin, E., Berezowski, V., Cecchelli, R., & Fenart, L. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res,2009, 1249: 34-42.doi:10.1016/j.brainres.2008.10.036
  • Hallier-Vanuxeem, D., Prieto, P., Culot, M., Diallo, H., Landry, C., Tahti, H., & Cecchelli, R. New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment. Toxicol In Vitro,2009, 23(3): 447-453.doi:10.1016/j.tiv.2008.12.011
  • Pottiez, G., Sevin, E., Cecchelli, R., Karamanos, Y., & Flahaut, C. Actin, gelsolin and filamin-A are dynamic actors in the cytoskeleton remodelling contributing to the blood brain barrier phenotype. Proteomics,2009, 9(5): 1207-1219.doi: 10.1002/pmic.200800503
  • Verhoeven, E., Siepmann, F., De Beer, T. R. M., Van Loo, D., Van den Mooter, G., Remon, J. P., Siepmann, J., & Vervaet, C. Modeling drug release from hot-melt extruded mini-matrices with constant and non-constant diffusivities. European Journal of Pharmaceutics and Biopharmaceutics,2009, 73(2): 292-301.doi:10.1016/j.ejpb.2009.06.010
  • Kranz, H., Jürgens, K., Pinier, M., & Siepmann, J. Drug release from MCC- and carrageenan-based pellets: Experiment and theory. European Journal of Pharmaceutics and Biopharmaceutics,2009, 73(2): 302-309.doi:10.1016/j.ejpb.2009.05.007
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L., Desreumaux, P., & Siepmann, J. Characterization of ethylcellulose: starch-based film coatings for colon targeting. Drug Development and Industrial Pharmacy,2009, 35(10): 1190-1200.doi:10.1080/03639040902858868
  • Bley, O., Siepmann, J., & Bodmeier, R. Importance of glassy-to-rubbery state transitions in moisture-protective polymer coatings. European Journal of Pharmaceutics and Biopharmaceutics,2009, 73(1): 146-153.doi:10.1016/j.ejpb.2009.05.001
  • Bley, O., Siepmann, J., & Bodmeier, R. Protection of moisture-sensitive drugs with aqueous polymer coatings: Importance of coating and curing conditions. International Journal of Pharmaceutics,2009, 378(1-2): 59-65.doi:10.1016/j.ijpharm.2009.05.036
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L. t., Flament, M.-P., Dubreuil, L., Desreumaux, P., & Siepmann, J. Novel polymeric film coatings for colon targeting: Drug release from coated pellets. European Journal of Pharmaceutical Sciences,2009, 37(3-4): 427-433.doi:10.1016/j.ejps.2009.03.014
  • Quinten, T., Gonnissen, Y., Adriaens, E., Beer, T. D., Cnudde, V., Masschaele, B., Van Hoorebeke, L., Siepmann, J., Remon, J. P., & Vervaet, C. Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose. European Journal of Pharmaceutical Sciences,2009, 37(3-4): 207-216.doi:10.1016/j.ejps.2009.02.006
  • Cosijns, A., Nizet, D., Nikolakakis, I., Vervaet, C., De Beer, T., Siepmann, F., Siepmann, J., Evrard, B., & Remon, J. P. Porous pellets as drug delivery system. Drug Development and Industrial Pharmacy,2009, 35(6): 655-662.doi:10.1080/03639040802578103
  • Moebus, K., Siepmann, J., & Bodmeier, R. Alginate-poloxamer microparticles for controlled drug delivery to mucosal tissue. European Journal of Pharmaceutics and Biopharmaceutics,2009, 72(1): 42-53.doi:10.1016/j.ejpb.2008.12.004
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L., Desreumaux, P., & Siepmann, J. r. Novel polymeric film coatings for colon targeting: How to adjust desired membrane properties. International Journal of Pharmaceutics,2009, 371(1-2): 64-70.doi:10.1016/j.ijpharm.2008.12.014
  • Bley, O., Siepmann, J., & Bodmeier, R. Characterization of moisture-protective polymer coatings using differential scanning calorimetry and dynamic vapor sorption. Journal of Pharmaceutical Sciences,2009, 98(2): 651-664.doi:10.1002/jps.21429
  • Glaessl, B., Siepmann, F., Tucker, I., Siepmann, J., & Rades, T. Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate. European Journal of Pharmaceutics and Biopharmaceutics,2009, 73(3): 366-372.doi:10.1016/j.ejpb.2009.07.010
  • Ho, L., Cuppok, Y., Muschert, S., Gordon, K. C., Pepper, M., Shen, Y., Siepmann, F., Siepmann, J., Taday, P. F., & Rades, T. Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: A case study using terahertz pulsed imaging. International Journal of Pharmaceutics,2009, 382(1-2): 151-159.doi:10.1016/j.ijpharm.2009.08.025
  • Danel, C., Azaroual, N., Brunel, A., Lannoy, D., Odou, P., Decaudin, B., Vermeersch, G., Bonte, J.-P., & Vaccher, C. Configurational stability of 9-hydroxyrisperidone. Kinetics and mechanism of racemization. Tetrahedron: Asymmetry,2009, 20(10): 1125-1131.doi:10.1016/j.tetasy.2009.02.034
  • Lipka, E., Vaccher, C., Bonte, J.-P., & Foulon, C. Chiral Separation of Four Piperidinic Benzoxazolinone Compounds by CE and LC. Chromatographia,2009, 69(9): 903-909.doi: 10.1365/s10337-009-1026-y
  • Lipka, E., Vaccher, C., & Bonte, J.-P. Enantiomeric Resolution of Benzoxazolinonic Aminoalcohols, Potential Adrenergic Ligands, by LC and CE. Chromatographia,2009, 69(5): 465-472.doi: 10.1365/s10337-008-0940-8
  • Flipo, M., Charton, J., Hocine, A., Dassonneville, S., Deprez, B., & Deprez-Poulain, R. Hydroxamates: Relationships between structure and plasma-stability. J Med Chem,2009, 52(21): 6790-6802 doi:10.1021/jm900648x
  • Dumoulin, D., Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Asymmetric synthesis of 3- or 4-alkyl or arylbenzo[c]azepines. Tetrahedron: Asymmetry,2009, 20(16): 1903-1911 doi:10.1016/j.tetasy.2009.07.015
  • Lipka, E., Charton, J., Vaccher, M.-P., Folly-Klan, M., Bonte, J.-P., & Vaccher, C. Enantioseparation of chiral benzimidazole derivatives by electrokinetic chromatography using sulfated cyclodextrins. Journal of Separation Science,2009, 32(11): 1907-1915 doi:10.1002/jssc.200800713
  • Foulon, C., Tedou, J., Queruau-Lamerie, T., Vaccher, C., Bonte, J.-P., Goossens, J.-F. Assessment of the complexation degree of camptothecin derivatives and cyclodextrins using spectroscopic and separatives methodologies; 2009, 20, 2482-2489
  • Dumoulin, D.,  Lebrun, S., Couture, A., Deniau, E., Grandclaudon, P. Asymmetric synthesis of 3- or 4-alkyl or arylbenzo[c]azepines; 2009, 20, 1903–1911
  • Charton, J., Deprez-Poulain, R., Hennuyer, N., Tailleux, A., Staels, B., & Deprez, B. Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives. Bioorganic & Medicinal Chemistry Letters,2009, 19(2): 489-492 doi:10.1016/j.bmcl.2008.11.40.
  • Willand, N., Dirié, B., Carette, X., Bifani, P., Singhal, A., Desroses, M., Leroux, F., Déprez-Poulain, R., Frénois, F., Aumercier, M., Locht, C., Villeret, V., Déprez, B., & Baulard, A. Synthetic EthR inhibitors boost anti-tuberculous activity of ethionamide. Nature Medicine,2009, 15: 537-544 doi:10.1038/nm.1950
  • Lipka, E., Vaccher, C., Bonte, J.-P., Foulon, C. Capillary Electrophoresis and High Performance Liquid Chromatography for Chiral Separation of Four Piperidinic Benzoxazolinone Compounds; 2009, 69, 903-909,
  • Lipka, E., Vaccher,  C., Bonte. J.-P.  amino alcohols, potential adrenergic ligands, by LC and CE; 2009 69, 465-472
  • Danel, C., Azaroual,  N., Lannoy, D., Brunel, A., Odou, P., Decaudin, B., Vermeersch, G., Bonte, J.-P., Vaccher, C. Chiral stability of the 9-hydroxyrisperidone. Kinetics and mechanism of racemization; 2009 20(10), 1125-1131
  • Muschert, S., Siepmann, F., Leclercq, B., Carlin, B., & Siepmann, J. Prediction of drug release from ethylcellulose coated pellets. Journal of Controlled Release,2009, 135(1): 71-79 doi:10.1016/j.jconrel.2008.12.003
  • Muschert, S., Siepmann, F., Leclercq, B., Carlin, B., & Siepmann, J. Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets. European Journal of Pharmaceutics and Biopharmaceutics,2009, 72(1): 130-137 doi:10.1016/j.ejpb.2008.12.007
  • Muschert, S., Siepmann, F., Cuppok, Y., Leclercq, B., Carlin, B., & Siepmann, J. Improved long term stability of aqueous ethylcellulose film coatings: Importance of the type of drug and starter core. International Journal of Pharmaceutics,2009, 368(1-2): 138-145 doi:10.1016/j.ijpharm.2008.10.005
  • Klose, D., Azaroual, N., Siepmann, F., Vermeersch, G., & Siepmann, J. Towards More Realistic In vitro Release Measurement Techniques for Biodegradable Microparticles. Pharmaceutical Research,2009, 26(3): 691-699 doi:10.1007/s11095-008-9747-4
  • Klose, D., Laprais, M., Leroux, V., Siepmann, F., Deprez, B., Bordet, R., & Siepmann, J. Fenofibrate-loaded PLGA microparticles: Effects on ischemic stroke. European Journal of Pharmaceutical Sciences,2009, 37(1): 43-52 doi:10.1016/j.ejps.2008.12.016
  • Karrout, Y., Neut, C., Wils, D., Siepmann, F., Deremaux, L., Dubreuil, L., Desreumaux, P., & Siepmann, J. Colon targeting with bacteria-sensitive films adapted to the disease state. European Journal of Pharmaceutics and Biopharmaceutics,2009, 73(1): 74-81 doi:10.1016/j.ejpb.2009.04.003
  • Ho, L., Cuppok, Y., Muschert, S., Gordon, K.-C., Pepper, M., Shen, Y., Siepmann, F., Siepmann, J., Taday, P.-F.,Rades, T. Effects of film coating thickness and drug layer uniformity on in-vitro drug release from sustained-release coated pellets: A case study using terahertz pulsed imaging, 2009, 382(1-2), 151-159, doi:10.1016/j.ijpharm.2009.08.025
  • B. Glaessl, F. Siepmann, I. Tucker, J. Siepmann, T. Rades. Characterization of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate; 2009
  • Foulon, C., Tedou, J., Queruau Lamerie, T., Vaccher, C., Bonte, J. P., & Goossens, J. F. Assessment of the complexation degree of camptothecin derivatives and cyclodextrins using spectroscopic and separative methodologies. Tetrahedron: Asymmetry,2009, 20(21): 2482-2489 doi:10.1016/j.tetasy.2009.10.029
  • Thiry, A., Delayen, A. l., Goossens, L., Houssin, R., Ledecq, M., Frankart, A. l., Dogné, J.-M., Wouters, J., Supuran, C. T., Hénichart, J.-P., & Masereel, B. Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors. European Journal of Medicinal Chemistry,2009, 44(2): 511-518 doi:10.1016/j.ejmech.2008.03.034 

2008

  • Garat, A., Cauffiez, C., Renault, N., Lo-Guidice, J. M., Allorge, D., Chevalier, D., Houdret, N., Chavatte, P., Loriot, M. A., Gala, J. L., & Broly, F. Characterisation of novel defective thiopurine S-methyltransferase allelic variants. Biochem Pharmacol,2008, 76(3): 404-415.doi.org/10.1016/j.bcp.2008.05.009
  • Kambia, N., Renault, N., Dilly, S., Farce, A., Dine, T., Gressier, B., Luyckx, M., Brunet, C., & Chavatte, P. Molecular modelling of phthalates - PPARs interactions. J Enzyme Inhib Med Chem,2008, 23(5): 611-616
  • Farce, A., Chugunov, A. O., Loge, C., Sabaouni, A., Yous, S., Dilly, S., Renault, N., Vergoten, G., Efremov, R. G., Lesieur, D., & Chavatte, P. Homology modeling of MT1 and MT2 receptors. Eur J Med Chem,2008, 43(9): 1926-1944.doi.org/10.1016/j.ejmech.2007.12.001,
  • Poissonnier-Durieux, S., Ettaoussi, M., Peres, B., Boutin, J. A., Audinot, V., Bennejean, C., Delagrange, P., Caignard, D. H., Renard, P., Berthelot, P., Lesieur, D., & Yous, S. Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem,2008, 16(18): 8339-8348.doi.org/10.1016/j.bmc.2008.08.052,
  • Ettaoussi, M., Peres, B., Klupsch, F., Delagrange, P., Boutin, J. A., Renard, P., Caignard, D. H., Chavatte, P., Berthelot, P., Lesieur, D., & Yous, S. Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem,2008, 16(9): 4954-4962.doi.org/10.1016/j.bmc.2008.03.036
  • Alkhatib, R., Hennebelle, T., Joha, S., Idziorek, T., Preudhomme, C., Quesnel, B., Sahpaz, S., & Bailleul, F. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines. Phytochemistry,2008, 69(17): 2979-2983.doi.org/10.1016/j.phytochem.2008.09.019,
  • Hennebelle, T., Sahpaz, S., Joseph, H., & Bailleul, F. Ethnopharmacology of Lippia alba. J Ethnopharmacol,2008, 116(2): 211-222.dx.doi.org/10.1016/j.jep.2007.11.044,
  • Zamble, A., Martin-Nizard, F., Sahpaz, S., Hennebelle, T., Staels, B., Bordet, R., Duriez, P., Brunet, C., & Bailleul, F. Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots. J Ethnopharmacol,2008, 116(1): 112-119.dx.doi.org/10.1016/j.jep.2007.11.016
  • Zamble, A., Sahpaz, S., Brunet, C., & Bailleul, F. Effects of Microdesmis keayana roots on sexual behavior of male rats. Phytomedicine,2008, 15(8): 625-629.doi.org/10.1016/j.phymed.2007.10.002,
  • Hennebelle, T., Sahpaz, S., Gressier, B., Joseph, H., & Bailleul, F. Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba. Phytother Res,2008, 22(2): 256-258.DOI: 10.1002/ptr.2266
  • Lorion, M., Couture, A., Deniau, E., & Grandclaudon, P. A Concise Synthesis of Mono- and Polysubstituted and Diversely N-FunctionÂalized Isoindolinones and Isoquinolones. Synthesis,2008, 2008(EFirst): 2141-2147.doi: 10.1055/s-2008-1067125
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Strategy for the Assembly of Chiral Bicyclic Lactams: A Concise Synthetic Route to (-)-Coniceine. Synthesis,2008, 2008(EFirst): 2771-2775.doi: 10.1055/s-2008-1067204
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Asymmetric synthesis of the optically active piperidine alkaloid (+)-β-conhydrine. Tetrahedron: Asymmetry,2008, 19(10): 1245-1249.doi:10.1016/j.tetasy.2008.04.021
  • Lamblin, M., Couture, A., Deniau, E., & Grandclaudon, P. Alternative and complementary approaches to the asymmetric synthesis of C3 substituted NH free or N-substituted isoindolin-1-ones. Tetrahedron: Asymmetry,2008, 19(1): 111-123.doi:10.1016/j.tetasy.2007.11.014
  • Deniau, E., Couture, A., & Grandclaudon, P. A conceptually new approach to the asymmetric synthesis of 3-aryl and alkyl poly-substituted isoindolinones. Tetrahedron: Asymmetry,2008, 19(23): 2735-2740.doi:10.1016/j.tetasy.2008.11.021
  • Richard, A., Barras, A., Younes, A. B., Monfilliette-Dupont, N., & Melnyk, P. Minimal Chemical Modification of Reductive End of Dextran to Produce an Amphiphilic Polysaccharide Able to Incorporate onto Lipid Nanocapsules. Bioconjugate Chemistry,2008, 19(7): 1491-1495.doi: 10.1021/bc700444t
  • Paunescu, E., Susplugas, S., Boll, E., Varga, R. A., Mouray, E., Grellier, P., & Melnyk, P. Synthesis and Antimalarial Activity of New Amino Analogues of Amodiaquine. Medicinal Chemistry,2008, 4(5): 407-425.doi:10.2174/157340608785700153
  • Delarue-Cochin, S., Grellier, P., Maes, L., Mouray, E., Sergheraert, C., & Melnyk, P. Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. European Journal of Medicinal Chemistry,2008, 43(10): 2045-2055.doi:10.1016/j.ejmech.2007.11.003
  • Delarue-Cochin, S., Paunescu, E., Maes, L., Mouray, E., Sergheraert, C., Grellier, P., & Melnyk, P. Synthesis and antimalarial activity of new analogues of amodiaquine. European Journal of Medicinal Chemistry,2008, 43(2): 252-260.doi:10.1016/j.ejmech.2007.03.008
  • Magazù, S., Maisano, G., Migliardo, F., Galli, G., Benedetto, A., Morineau, D., Affouard, F., & Descamps, M. Characterization of molecular motions in biomolecular systems by elastic incoherent neutron scattering. Journal of Chemical Physics,2008, 129: 155103.doi: 10.1063/1.2989804
  • Affouard, F., Lerbret, A., Hédoux, A., Guinet, Y., & Descamps, M. Biopreservative capabilities of disaccharides on proteins: A study by molecular dynamics simulations. AIP Conference Proceedings,2008, 982: 690-695.doi: 10.1063/1.2897879
  • Habasaki, J., Affouard, F., Descamps, M., & Ngai, K. L. Molecular dynamics of generalized binary lennard-jones systems: Effects of anharmonicity and breakdown of the stokes-Einstein relation. AIP Conference Proceedings,2008, 982: 154-159.doi: 10.1063/1.2897773
  • Willart, J. F., Descamps, M., & Caron, V. Direct crystal to glass transformations of trehalose induced by milling, dehydration and annealing. AIP Conference Proceedings,2008, 982: 108-113.doi: 10.1063/1.2897763
  • Dudognon, E., Danède, F., Descamps, M., & Correia, N. Evidence for a New Crystalline Phase of Racemic Ibuprofen. Pharmaceutical Research,2008, 25(12): 2853.doi:10.1007/s11095-008-9655-7
  • Hedoux, A., Guinet, Y., Capet, F., Paccou, L., & Descamps, M. Evidence for a high-density amorphous form in indomethacin from Raman scattering investigations. Physical Review B,2008, 77(9): 094205.doi:10.1103/PhysRevB.77.094205
  • Decroix, A. A., Carpentier, L., & Descamps, M. Time-resolved dielectric investigation of relaxation kinetics in metastable caffeine. Philosophical Magazine,2008, 88(33-35): 3925.doi:10.1080/14786430802585125
  • Derollez, P., Dudognon, E., Affouard, F., Danede, F., Correia, N. T., & Descamps, M. Ab initio structure determination of phase II of racemic ibuprofen by X-ray powder diffraction. Acta Crystallographica Section B,2008, 66(1): 76-80.doi:10.1107/S0108768109047363
  • Willart, J. F., & Descamps, M. Solid State Amorphization of Pharmaceuticals. Molecular Pharmaceutics,2008, 5(6): 905-920.doi: 10.1021/mp800092t
  • Lerbret, A., Affouard, F., Bordat, P., Hédoux, A., Guinet, Y., & Descamps, M. Molecular dynamics simulations of lysozyme in water/sugar solutions. Chemical Physics,2008, 345(2-3): 267-274.doi:10.1016/j.chemphys.2007.09.011
  • Thi, T. H. H., Danède, F., Descamps, M., & Flament, M.-P. Comparison of physical and inhalation properties of spray-dried and micronized terbutaline sulphate. European Journal of Pharmaceutics and Biopharmaceutics,2008, 70(1): 380-388.doi:10.1016/j.ejpb.2008.04.002
  • Dujardin, N., Willart, J. F., Dudognon, E., Hédoux, A., Guinet, Y., Paccou, L., Chazallon, B., & Descamps, M. Solid state vitrification of crystalline and -D-glucose by mechanical milling. Solid State Communications,2008, 148(1-2): 78-82.doi:10.1016/j.ssc.2008.07.002
  • De Gusseme, A., Neves, C., Willart, J. F., Rameau, A., & Descamps, M. Ordering and disordering of molecular solids upon mechanical milling: The case of fananserine. Journal of Pharmaceutical Sciences,2008, 97(11): 5000-5012.doi: 10.1002/jps.21472
  • Bras, A. R., Noronha, J., Antunes, A. M. M., Cardoso, M. M., Schöhals, A., Affouard, F., Dionisio, M., & Correia, N. T. Molecular Motions in Amorphous Ibuprofen As Studied by Broadband Dielectric Spectroscopy. The Journal of Physical Chemistry B,2008, 112(35): 11087-11089.doi: 10.1021/jp8040428
  • Stern, E., Goossens, L., Vaccher, C., Bonte, J. P., Depreux, P., Henichart, J. P., & Goossens, J. F. Chiral resolution of the enantiomers of new selective CB(2) receptor agonists by liquid chromatography on amylose stationary phases. J Pharm Biomed Anal,2008, 46(5): 848-853.dx.doi.org/10.1016/j.jpba.2007.01.044
  • Ryckebusch, A., Garcin, D., Lansiaux, A., Goossens, J. F., Baldeyrou, B., Houssin, R., Bailly, C., & Henichart, J. P. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives. J Med Chem,2008, 51(12): 3617-3629.DOI: 10.1021/jm800017u
  • Culot, M., Lundquist, S., Vanuxeem, D., Nion, S., Landry, C., Delplace, Y., Dehouck, M. P., Berezowski, V., Fenart, L., & Cecchelli, R. An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening. Toxicol In Vitro,2008, 22(3): 799-811.doi:10.1016/j.tiv.2007.12.016
  • Charton, J., Leroux, F., Delaroche, S., Landry, V., Deprez, B. P., & Deprez-Poulain, R. F. Synthesis of a Library of 200-Member Squaric Acid N-Hydroxylamide Amides. Bioorganic & Medicinal Chemistry Letters,2008, 18(18): 4968-4971.doi:10.1016/j.bmcl.2008.08.025
  • Charton, J., Charruault, L., Deprez-Poulain, R., & Deprez, B. Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds. Combinatorial Chemistry and High Throughput Screening,2008, 11(4): 294-303
  • Cousaert, N., Willand, N., Gesquiere, J.-C., Tartar, A., Deprez, B., & Deprez-Poulain, R. Original loading and Suzuki conditions for the solid-phase synthesis of biphenyltetrazoles. Application to the first solid-phase synthesis of irbesartan. Tetrahedron Letters,2008, 49: 2743-2747.doi:10.1016/j.tetlet.2008.02.147
  • Vaccher, M.-P., Charton, J., Guelzim, A., Caignard, D.-H., Bonte, J.-P., & Vaccher, C. Preparative Enantiomeric Separation of Potent AMP-Activated Protein Kinase Activator by HPLC on Amylose-Based Chiral Stationary Phase. Determination of Enantiomeric Purity and Assignment of Absolute Configuration. Journal of Pharmaceutical and Biomedical Analysis,2008, 46(5): 920-928
  • Villoutreix, B. O., Bastard, K., Sperandio, O., Fahraeus, R., Poyet, J. L., Calvo, F., Deprez, B., & Miteva, M. A. In silico-in vitro screening of protein-protein interactions: towards the next generation of therapeutics. Current Pharmaceutical Biotechnology,2008, 9(2): 103-122
  • Beghyn, T., Deprez-Poulain, R., Willand, N., Foleas, B., & Deprez, B. Natural compounds: leads or ideas? Bioinspired molecules for drug discovery. Chemical Biology and Drug Design,2008, 72: 3-15.doi:10.1111/j.1747-0285.2008.00673.x
  • Danel, C., Azaroual, N., Brunel, A., Lannoy, D., Vermeersch, G., Odou, P., & Vaccher, C. Study of the complexation of risperidone and 9-hydroxyrisperidone with cyclodextrin hosts using affinity capillary electrophoresis and 1H NMR spectroscopy. Journal of Chromatography A,2008, 1215(1-2): 185-193.doi:10.1016/j.chroma.2008.10.094
  • Goossens, J. F., Roux, S., Egron, D., Perigaud, C., Bonte, J. P., Vaccher, C., & Foulon, C. Separation of nucleoside phosphoramidate diastereoisomers by high performance liquid chromatography and capillary electrophoresis. Journal of Chromatography B,2008, 875(1): 288-295.doi:10.1016/j.jchromb.2008.06.056

2007

  • Durand, A. C., Farce, A., Carato, P., Dilly, S., Yous, S., Berthelot, P., & Chavatte, P. Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives. J Enzyme Inhib Med Chem,2007, 22(5): 556-562
  • Duriez, P., Bordet, R., & Berthelot, P. The strange case of Dr HDL and Mr HDL: does a NO's story illuminate the mystery of HDL's dark side uncovered by Dr HDL's drug targeting CETP? Med Hypotheses,2007, 69(4): 752-757.doi:10.1016/j.mehy.2007.01.059
  • Zamble, A., Hennebelle, T., Sahpaz, S., & Bailleul, F. Two new quinoline and tris(4-hydroxycinnamoyl)spermine derivatives from Microdesmis keayana roots. Chem Pharm Bull (Tokyo),2007, 55(4): 643-645.DOI:10.1248/cpb.55.643
  • Lebrun, S. p., Couture, A., Deniau, E., & Grandclaudon, P. Asymmetric Synthesis of 6-Alkyl- and 6-Arylpiperidin-2-ones. Enantioselective Synthesis of (S)-(+)-Coniine. Organic Letters,2007, 9(13): 2473–2476.doi: 10.1021/ol070757w
  • Lamblin, M., Couture, A., Deniau, E., & Grandclaudon, P. A concise first total synthesis of narceine imide. Organic & Biomolecular Chemistry,2007, 5(9): 1466-1471.doi: 10.1039/B701661A
  • Lamblin, M., Couture, A., Deniau, E., & Grandclaudon, P. A concise and efficient synthesis of isoindolin-1-ones. New synthetic approach to the polycyclic framework of vitedoamine A. Tetrahedron,2007, 63(12): 2664-2669.doi:10.1016/j.tet.2007.01.021
  • Couture, A., Deniau, E., Lamblin, M., Lorion, M., & Grandclaudon, P. Preparation of Poly and Diversely Substituted N-Alkylated and Free-NH Isoindolin-1-ones. Synthesis,2007, 2007(EFirst): 1434-1437.doi: 10.1055/s-2007-965955
  • Paunescu, E., Matuszak, N., & Melnyk, P. Suzuki-Miyaura cross-coupling reaction as the key step for the synthesis of some new 4-aryl and alkyl substituted analogues of amodiaquine and amopyroquine. Tetrahedron,2007, 63(51): 12791-12810.doi:10.1016/j.tet.2007.08.115
  • Lefort, R., Bordat, P., Cesaro, A., & Descamps, M. Exploring the conformational energy landscape of glassy disaccharides by cross polarization magic angle spinning C13 nuclear magnetic resonance and numerical simulations. II. Enhanced molecular flexibility in amorphous trehalose.2007, 126: 014511.doi: 10.1063/1.2409935
  • Lefort, R., Bordat, P., Cesaro, A., & Descamps, M. Exploring conformational energy landscape of glassy disaccharides by cross polarization magic angle spinning C13 NMR and numerical simulations. I. Methodological aspects. Journal of Chemical Physics,2007, 126: 014510.doi: 10.1063/1.2409934
  • Shakhtshneider, T. P., Danède, F., Capet, F., Willart, J. F., Descamps, M., Surov, E. V., Boldyreva, E. V., & Boldyrev, V. V. Cryogenic grinding of indometacin with polyvinylpyrrolidone. Chemistry for Sustainable Development (in Russian),2007, (15): 209
  • Shakhtshneider, T. P., Danède, F., Capet, F., Willart, J. F., Descamps, M., Myz, S. A., Medvedeva, A. S., & Boldyrev, V. V. Effect of cryogenic grinding on physical-chemical properties of piroxicam and its mixtures with polyvinylpyrrolidone. Chemistry for Sustainable Development (in Russian),2007, (15): 201
  • Willart, J., Caron, V., & Descamps, M. Transformations of crystalline sugars upon milling. Journal of Thermal Analysis and Calorimetry,2007, 90(1): 125.doi:10.1007/s10973-007-8485-x
  • Shakhtshneider, T., Danède, F., Capet, F., Willart, J., Descamps, M., Paccou, L., Surov, E., Boldyreva, E., & Boldyrev, V. Grinding of drugs with pharmaceutical excipients at cryogenic temperatures. Journal of Thermal Analysis and Calorimetry,2007, 89(3): 709.doi:10.1007/s10973-006-7959-6
  • Shakhtshneider, T., Danède, F., Capet, F., Willart, J., Descamps, M., Myz, S., Boldyreva, E., & Boldyrev, V. Grinding of drugs with pharmaceutical excipients at cryogenic temperatures. Journal of Thermal Analysis and Calorimetry,2007, 89(3): 699.doi:10.1007/s10973-006-7958-7
  • Paccou, A. H. d. a. F. A. a. M. D. a. Y. G. a. L. Microscopic description of protein thermostabilization mechanisms with disaccharides from Raman spectroscopy investigations. Journal of Physics: Condensed Matter,2007, 19(20): 205142.doi:10.1088/0953-8984/19/20/205142
  • Lerbret, A., Bordat, P., Affouard, F., Hédoux, A., Guinet, Y., & Descamps, M. How Do Trehalose, Maltose, and Sucrose Influence Some Structural and Dynamical Properties of Lysozyme? Insight from Molecular Dynamics Simulations. The Journal of Physical Chemistry B,2007, 111(31): 9410-9420.doi: 10.1021/jp071946z
  • Descamps, M., Willart, J. F., Dudognon, E., & Caron, V. Transformation of pharmaceutical compounds upon milling and comilling: The role of Tg. Journal of Pharmaceutical Sciences,2007, 96(5): 1398-1407.doi: 10.1002/jps.20939
  • Caron, V., Willart, J. F., Danède, F., & Descamps, M. The implication of the glass transition in the formation of trehalose/mannitol molecular alloys by ball milling. Solid State Communications,2007, 144(7-8): 288-299.doi:10.1016/j.ssc.2007.09.006
  • Bordat, P., Affouard, F. d. r., & Descamps, M. Effect of anharmonicity on the diffusion in glassforming binary Lennard-Jones systems. Journal of Non-Crystalline Solids,2007, 353(41-43): 3924-3927.doi:10.1016/j.jnoncrysol.2007.02.065
  • Stern, E., Muccioli, G. G., Bosier, B., Hamtiaux, L., Millet, R., Poupaert, J. H., Henichart, J. P., Depreux, P., Goossens, J. F., & Lambert, D. M. Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality. J Med Chem,2007, 50(22): 5471-5484.DOI: 10.1021/jm070387h
  • Jallouli, Y., Paillard, A., Chang, J., Sevin, E., & Betbeder, D. Influence of surface charge and inner composition of porous nanoparticles to cross blood-brain barrier in vitro. Int J Pharm,2007, 344(1-2): 103-109.doi:10.1016/j.ijpharm.2007.06.023
  • Dubs, P., Bourel-Bonnet, L., Subra, G., Blanpain, A., Melnyk, O., Pinel, A. M., Gras-Masse, H., & Martinez, J. Parallel synthesis of a lipopeptide library by hydrazone-based chemical ligation. Journal of Combinatorial Chemistry,2007, 9(6): 973-981
  • Beghyn, T., Hounsou, C., & Deprez, B. P. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters,2007, 17(3): 789-792
  • Charton, J., Cousaert, N., Bochu, C., Willand, N., Deprez, B., & Deprez-Poulain, R. A versatile solid-phase synthesis of 3-aryl-1,2,4-oxadiazolones and analogues. Tetrahedron Letters,2007, 48(8): 1479-1483.doi:10.1016/j.tetlet.2006.12.050
  • Deprez-Poulain, R. F., Charton, J., Leroux, V., & Deprez, B. P. Convenient synthesis of 4H-1,2,4-triazole-3-thiols using di-2-pyridylthionocarbonate. Tetrahedron Letters,2007, 48(46): 8157-8162.doi:10.1016/j.tetlet.2007.09.094
  • Flipo, M., Beghyn, T., Charton, J., Leroux, V. A., Deprez, B. P., & Deprez-Poulain, R. F. A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. Bioorganic and Medicinal Chemistry,2007, 15(1): 63-76.doi:10.1016/j.bmc.2006.10.010 
  • Flipo, M., Beghyn, T., Leroux, V., Florent, I., Deprez, B. P., & Deprez-Poulain, R. F. Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents. Journal of Medicinal Chemistry,2007, 50(6): 1322-1334.DOI: 10.1021/jm061169b
  • Gilleron, P., Wlodarczyk, N., Houssin, R., Farce, A., Laconde, G., Goossens, J. F., Lemoine, A., Pommery, N., Henichart, J. P., & Millet, R. Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors. Bioorganic & Medicinal Chemistry Letters,2007, 17(19): 5465-5471.dx.doi.org/10.1016/j.bmcl.2007.07.002
  • Gras-Masse, H., & Willand, N. Neuraminidase inhibitors and risk of H5N1 influenza. Annales Pharmaceutiques Francaises,2007, 65(1): 50-57
  • Willand, N., Folléas, B., Boutillon, C., Verbraeken, L., Gesquiere, J.-C., Tartar, A., & Deprez, B. Efficient, Two-Step Synthesis Of N-Substituted Nortropinone Derivatives. Tetrahedron Letters,2007, 48(29): 5007-5011.dx.doi.org/10.1016/j.tetlet.2007.05.110,
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