CNRS UMR 8181

Director : Francine Agbossou-Niedercorn

USTL, CNRS, ENSCL, ECL

Lab Web page : -

Research themes (keywords) : Bio-organometallic molecules agains malaria and tuberculosis, bioroganometallic chemistry, anti-NK, enantioselective catalysis, supported catalysts for chemistry, catalyzed reactions and organic synthesis.

Technical expertise (keywords) : Asymetric or not organometallic catalysis, organometallic synthesis, molecular modeling, reactions under pressure, supported catalysis.

Recent publications :

• Nowicki A., Keldenich J., Agbossou-Niedercorn, F. Highly Selective Preparation of a Chiral Quaternary Allyl Aryl Piperidinedione by Palladium-Catalyzed Asymmetric Allylation Under Solid-Liquid Phase-Transfer Catalysis. Eur. J. Org. Chem. 2007.
• Baramee A., Coppin A., Mortuaire M., Pelinski L., Tomavo S., Brocard J. Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum. Bioorg Med Chem. 2006, 14, 1294-302.
• Daher W., Pelinski L., Klieber S., Sadoun F., Meunier V., Bourrié M., Biot C., Guillou F., Fabre G., Brocard J., Fraisse L., Maffrand J.P., Khalife J., Dive D. In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006, 34, 667-82
• Buisine E., de Villiers K., Egan T.J., Biot C. Solvent-induced-effects: self-association of positively charged systems. J. Am. Chem. Soc. 2006, 128, 12122.
• Biot C., Daher W., Ndiaye C.M., Melnyk P., Pradines B., Chavain N., Pellet A., Fraisse L., Pelinski L., Jarry C., Brocard J., Khalife J., Forfar-Bares I., Dive D. Probing the role of the covalent linkage of ferrocene into a chloroquine template. J. Med. Chem. 2006, 49, 4707-4714.

Contacts :

Francine Agbossou-Niedercorn DR CNRS
Christophe Biot MdC USTL
Lydie Pélinski MdC USTL