2012 May 9th 18h30-20h00 Innovation evening. Presentation of new drug approvals 2011-2012 :

2012 April 18th: Science Day at the Hall of Theses from the University of Lille 1, organized by the Committee of Direction of Prim.

Consult past events and seminars organized by PRIM :

New article about PRIM in Le Nouvel Observateur :

Keep informed on Scientific Meetings and grant filing.
Rester informé sur les manifestations scientifiques et les appels d'offre.

EA 2465 Physiopathology of the blood-brain barrier

Director: Roméo Cecchelli

Université d'Artois - Faculté des Sciences - Jean Perrin

Lab Web page : http://www.univ-artois.fr/recherche/unites-de-recherche/lbhe

Research themes :

Technical expertise :

5 Recent publications :

Candela P, Gosselet F, Saint-Pol J, Sevin E, Boucau MC, Boulanger E, Cecchelli R, Fenart L. Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein. J Alzheimers Dis. 2010 Sep 21.
Pottiez G, Flahaut C, Cecchelli R, Karamanos Y. Understanding the blood-brain barrier using gene and protein expression profiling technologies. Brain Res Rev. 2009 Sep 19.
Hallier-Vanuxeem D, Prieto P, Culot M, Diallo H, Landry C, Tähti H, Cecchelli R. New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment. Toxicol In Vitro. 2009 Apr;23(3):447-53. Epub 2008 Dec 24.
Culot M, Lundquist S, Vanuxeem D, Nion S, Landry C, Delplace Y, Dehouck MP, Berezowski V, Fenart L, Cecchelli R. An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening. Toxicol In Vitro. 2008 Apr;22(3):799-811.
Cecchelli, Berezowski, Lundquist, Culot, Renftel, Dehouck, Fenart. Modelling of the blood-brain barrier in drug discovery and development. Nat. Rev. Drug. Discov. 2007;6: 650-61.