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EA CMF 4478: Laboratory of Physical Organic Chemistry

Directors : Dr Axel COUTURE DR CNRS, Dr Philippe COTELLE Prof. ENSCL

USTL, CNRS, ENSCL

Lab Web page : http://www.ensc-lille.fr/art96-6-146-laboratoire-de-chimie-organique-et-macromoleculaire-umr-cnrs-8009.html
 
Research themes (keywords) : antitumoral, antiviral, antifibrillogene, natural products, alkaloids, polyphenols, asymmetric synthesis, drug design.

Technical expertise (keywords) : multistep organic synthesis techniques, polarimetry, photochemistry (various wavelenghts).

Recent publications :

  • Stereoselective Asymmetric Synthesis of (+)-Sedamine and (+)-Allosedamine S. Lebrun, A. Couture*, E. Deniau, P. Grandclaudon Chirality 2010, 22, 212-216.
  • First asymmetric synthesis of (un)substituted bridged tetrahydrobenzo[c]azepines D. Dumoulin, S. Lebrun, A. Couture*, E. Deniau, P. Grandclaudon Tetrahedron: Asymmetry 2010, 21, 195-201.
  • Cyclic Sulfamidates as Vehicles for the Synthesis of Poly and Diversely Substituted Benzosultames via Unusual S(O)2 O Bond Cleavage. Magali Lorion, Vangelis Agouridas, Axel Couture,* Eric Deniau, and Pierre Grandclaudon Org. Lett. 2010, 12(6), 1356-1359.
  • Total asymmetric synthesis of boehmeriasin A.D. Dumoulin, S. Lebrun, A. Couture*, E. Deniau, P. Grandclaudon Eur. J. Org. Chem. 2010, 1943-1950.
  • Synthesis and cytotoxic evaluation of cis-locked and constrained analogues of combretastatin and combretastatin A4  M. Lorion, V. Agouridas, A. Couture*, E. Deniau, P. Grandclaudon Tetrahedron Lett. 2010, 51, 5146-5149.

Contacts :

Axel Couture, Dr. CNRS
Philippe Cotelle, Prof. ENSCL
Pierre Grandclaudon, Prof. ENSCL
Eric Deniau, Prof. USTL
Stephane Lebrun, Dr. MDC USTL
Fabrice Bailly, Dr. MDC USTL
Adina Ryckebusch, Dr. MDC ENSCL