INSERM U761

Director : Pr. Benoit Deprez

INSERM – Lille2 University (IFR114) – Pasteur Institute Lille (IFR142)

Lab Web page : http://www.deprezlab.fr

Research themes : medicinal chemistry, HTS, acidic compounds and metalloproteases, antituberculosis agents, antimalarials, inhibitors of protein-protein interactions, phosphodiesterases.

Technical expertise : HTS, parallel synthesis, medicinal chemistry, data-pipelining, solid phase synthesis, early ADME (Solubility, LogD, Biological fluids stability, Plasma protein binding, Microsomes stability, CYP metabolism) cellular culture, enzymology, Pd- and Cu-catalyzed reactions, heterocyclic chemistry.

5 Recent publications :

2010

• Reynes, C., Host, H., Camproux, A.-C., Laconde, G., Leroux, F., Mazars, A., Deprez, B., Fahraeus, R., Villoutreix, B. O., & Sperandio, O. Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods. Plos Computaional Biology, 2010, 6(3): e1000695.
  doi:10.1371/journal.pcbi.1000695

2009

• Flipo, M., Charton, J., Hocine, A., Dassonneville, S., Deprez, B., & Deprez-Poulain, R. Hydroxamates: Relationships between structure and plasma-stability. J Med Chem, 2009, 52(21): 6790-6802.
  doi:10.1021/jm900648x
• Willand, N., Dirié, B., Carette, X., Bifani, P., Singhal, A., Desroses, M., Leroux, F., Déprez-Poulain, R., Frénois, F., Aumercier, M., Locht, C., Villeret, V., Déprez, B., & Baulard, A. Synthetic EthR inhibitors boost anti-tuberculous activity of ethionamide. Nature Medicine, 2009, 15: 537-544.
  doi:10.1038/nm.1950
• Charton, J., Deprez-Poulain, R., Hennuyer, N., Tailleux, A., Staels, B., & Deprez, B.
  Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives.
  Bioorganic & Medicinal Chemistry Letters, 2009, 19(2): 489-492.
  doi:10.1016/j.bmcl.2008.11.040
• Klose, D., Laprais, M., Leroux, V., Siepmann, F., Deprez, B., Bordet, R., & Siepmann, J.
  Fenofibrate-loaded PLGA microparticles: Effects on ischemic stroke.
  European Journal of Pharmaceutical Sciences, 2009, 1:43-52.
  doi:10.1016/j.ejps.2008.12.016

Contacts :

Benoit Déprez
Rebecca Déprez-Poulain
Terence Beghyn
Nicolas Willand
Julie Charton
Guillaume Laconde
Jean-Claude Gesquière
Marion Flipo
Florence Leroux